Congratulations to everyone on this collaboration between the Soltesz and Deisseroth labs - using the transformative eCB-GRAB sensors by Yulong Li, we demonstrated depolarization-induced suppression if inhibition (DSI) in behaving mice. DSI is a form of short-term plasticity at GABAergic synapses that has been described over 30 years ago in vitro, and finally we have the tools and approaches to test synaptic plasticity mechanisms like DSI during behavior.